产品货号：
Z19221
中文名称：
Lamin A/C抗体
英文名称：
Anti-Lamin A/C Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Lamin A/C Antibody |
| 指标别名 | 70kDa lamin;CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;HGPS;IDC;lamin A;lamin A/C;LDP1;LFP;LGMD1B;LMN1;LMNA;LMNC;Prelamin A/C;PRO1;progerin |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF,FCM,ICC/IF |
| 基因名称 | LMNA |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Lamin A/C recombinant protein (Position:Y481-Y646).Human Lamin A/C shares 90% and 92% amino acid (aa) sequence identity with mouse and rat Lamin A/C,respectively. |
| 计算分子量 | 74KD |
| 实际分子量 | 74KD,63KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Lamins are structural protein components of the nuclear lamina,a protein network underlying the inner nuclear membrane that determines nuclear shape and size.There are three types of lamins,A,B and C.The lamin A/C (LMNA) gene contains 12 exons.Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C.Lamin A/C is mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy,dilated cardiomyopathy,and Hutchinson-Gilford progeria syndrome.Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription. |
| Uniprot ID | P02545 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | lamin A/C |
| 蛋白名全称 | Prelamin-A/C |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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